Pair Name	Tetrahydrocurcumin, Celecoxib
Disease Info	[ICD-11: 2C77.Z]	Cervical cancer		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	MVD	hsa4597
	Down-regulation	Expression	PTGS2	hsa5743
	Down-regulation	Expression	EGFR	hsa1956
In Vitro Model	Ca Ski	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_1100
In Vivo Model	To evaluate the combinational treatment effect of THC and celecoxib on tumor progression and tumor angiogenesis in cervical cancer (CaSki)-implanted nude mice.
Result	The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumor angiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. However, this combined treatment did not show the synergistic effect on inhibiting the tumor growth and tumor angiogenesis in cervical cancer (CaSki)-implanted nude mice model.